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How To Prevent Breakouts From Darkening Into Age Spots
Cosmeceutical Ingredients
A cosmeceutical ingredient is a potent and targeted active carefully chosen for its biological properties to fight the oxidative process and reduce unwanted signs of aging. BioRenew Skincare® utilizes the most advanced technologies and recovery compounds that are proven to fight the aging process, revealing beautiful and radiant skin.

Vitamin C: When stabilized, Vitamin C is the most important anti-oxidant found in the skin to protect against UV induced damage.
• Vitamin C is widely believed to be essential for collagen production and is proven to promote visible firmness in clinical studies.
• It dramatically brightens the appearance of skin tone while reducing the look of unwanted age spots.
• In vitro tests show an 80% decrease in melanogenesis when treated with Vitamin C Ester.
Ergothioneine (EGT): EGT is a naturally occurring anti-oxidant that recycles and restores Vitamin C to maintain potent anti-oxidant activity.
• EGT is superior to CoQ-10 and Idebenone at reducing the levels of Reactive Oxygen Species (ROS), which are responsible for oxidizing the skin.
Retinol MT: Retinol Microtechnology (MT) allows for a stabilized delivery for decreased irritation potential while preventing the look of premature skin aging.
• It clinically reduced the appearance of fine wrinkling and skin roughness after 4 weeks of use of topical application.
Niacinamide: When applied topically, this B vitamin was shown to have many beneficial effects on aging skin including: significantly reducing the appearance of hyperpigmentation, and enhancing the brightness of skin tone.
Derma-Peptides: A group of signaling peptides that have significant visible anti-wrinkle activity.
• Palmitoyl Tripeptide-3: After clinical use, 60% of patients reported improvement in the appearance of Crow’s Feet around the eyes.
• Tri-Peptide-10: In a clinical study, it induced a 54% increase in skin suppleness.
Highly Purified Micro-Algae: Patients report a 120% greater visible tightening effect compared to placebo.
Glycolic Acid: An alpha-hydroxy acid that encourages cell turnover and reduces redness.
Micro-Encapsulated Salicylic Acid: Controls breakouts and unwanted blemishes through a sustained release action. This formulation maintains a healthy pH and reduces irritations.
Anthemis Nobilis (Chamomile) Flower Extract: A biotanical ingredient that is used to calm and soothe skin for a fresh and clean finish.
Allantoin: Removes redness and inflammation.
Zinc Gluconate: A mineral that has natural skin clarifying and enhancing benefits. It has been show to prevent destruction of collagen proteins.
Niacinamide: This B-vitamin is proven to have beneficial breakout and age-management benefits while smoothing out skin tone
Grape Seed Oil: Contains anti-oxidants and essential fatty acids which restore a natural moisture barrier and softens skin.
Vitamin A: Supports healthy skin turnover and adds anti-oxidant protection.
Vitamin E: Prevents oxidation of the lipid barriers in the skin tissue.
Phospholipids: Hydrates deep layers of skin while repairing environmental damage.
Hyaluronic acid: This ingredient holds 1000 times its weight in water and hydrates the skin.
Green Tea Leaf Extract: Contains high amounts of polyphenols which prevent oxidative stress caused by UV radiation.
Licorice Root: Shown to have significant skin benefits while reducing the appearance of uneven skin tone and dark spots.
Micro-Algae Broth: A natural biotanical that positively effects skin tone and reduces hormonally induced age spots.
Olive Oil (polyphenols): Provides superior hydration and anti-oxidant properties.
Caffeine: Provides eye area benefits while reducing puffiness.
Euphrasia Officinalis (Eyebright): Extract A biotanical that is used to soothe and tone the eye contour area.
1 Dayan Nava, Skin Aging Handbook: An Integrated Approach to Biochemistry and Product Development, 149-176, Copyright 2008 William Andrew Inc.
2 Humbert PG, Haftek M, et al. Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo. Exp Dermatol. 2003 Jun;12(3):237-44
3 Kameyama K, Sakai C, et al. Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis. J Am Acad Dermato. 1996 Jan;34(1):29-33.
4 BV-OSC (Tetrahexyldecyl Ascorbate): A stable, oil-soluble form of Vitamin C. Barnet Product Corporation Dossier. Accessed 2011
5 Thiotaine. Barnet Products Corporation Dossier. Accessed 2011.
6 Dong K, Damaghi N, et al. A comparison of the relative antioxidant potency of L-ergothioneine. Journal of Cosmetic Dermatology. 2007 (6):183-188
7 Kafi R, Kwak H, et al. Improvement of Naturally Aged Skin With Vitamin A (Retinol). Arch Dermatol. 2007 May (143):606-612
8 Tucker-Samaras S, Zedayko T, et al. A stabilized 0.1% retinol facial moisturizer improves the appearance of photodamaged skin in an eight-week, double-blind, vehicle-controlled study. J Drugs Dermatol. 2009 Oct;8(10):932-6.
9 Gorouhi F, Maibachi H. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci 2009 (31): 327-345
10 Syn®-Coll. Pentapharm Ltd. Dossier. Access 2011
11 Puig A, Anton J, et al. A new decorin-like tetrapeptide for optimal organization of collagen fibres. Int J Cosmet Sci 2008(30): 97-104









