Rick Rhoads, Pharm.D

The Science of Menopause and Skin Care

Hormones play a vital role to keep your skin firm, healthy, and glowing. Naturally, a sudden decline in estrogens alters the way your skin looks and behaves. It can swiftly bring many unwanted signs of aging including: loss of firmness, dryness, wrinkles, age spots, and a dull skin tone. Menopause brings change to your life and your skin.

Changes To Your Skin During Menopause

Every layer of your skin is effected by the dramatic shifts that occur during this time period. We’ll discuss the two main layers of your skin and the physiological changes that contribute to accelerated aging.

The Epidermis

This is the top protective layer of your skin which contains cells called keratinocytes and natural moisturizing factors like hyaluronic acid. Normally this layer prevents water loss and keeps your skin smooth and hydrated. Menopause contributes to the break down of this layer and makes your skin more prone to being dry and irritated.

The epidermis also contains melanocytes which are cells that produce pigment called melanin. These cells are also worse off during menopause and more susceptible to disfunction which causes age spots, irregular pigmentation, and dull skin tone.

The Dermis

The dermis is the lower layer of skin responsible for collagen and elastin production. This gives your skin firmness and elasticity. A rapid decline in estrogen diminishes the production of collagen and elastin. It also speeds up their breakdown through enzymes called Matrix Metallo-Proteinases (MMP’s). This process can be dramatic during menopause which is why most women lose 30% of their skin collagen during the first 3 years of menopause.

Specialized Skin Care For Women In Menopause

We realize that women’s skin evolves as they age, and we want to change how they solve their skin care needs. While other companies are creating generic, mass-produced, one-size-fits-none products, we focused on just the opposite – targeted, highly specialized skincare. Although BioRenew does not treat menopause and it does not contain hormones, it is specialized for the common skin care needs of women in menopause.

Scientifically Proven Ingredients

Since our products are formulated by a compounding pharmacist, marketing hype will never replace real science and compounding experience.

We believe that good skin care formulas deliver amazing visible results. The core of our formulas are centered on tried-and-true sciences.

BioRenew Skincare formulas are targeted for the skin care needs of menopausal women and contain effective concentrations for visible rejuvenation that are backed by clinical science.

Vitamin C

Vitamin C is recognized by the scientific community as being the most important water-soluble antioxidant for your skin. It has been proven in numerous studies to promote a smoother and firmer appearance for women in menopause.

Concentrations that range from 5 - 10% are most effective in clinical trials but the downside is that they oxidize quickly. BioRenew uses a blend of several forms of Vitamin C to enhance stability and efficacy, even at a final concentration of 10%.


Retinoids have been studied for several decades and continue to be the most popular topical treatment for visible aging, sun damage, and wrinkles.

Concentrations of Retinol have been studied in ranges of 0.1 - 0.4%. As the potency increases, the likelihood of redness and irritation does as well. Many skin care lines boast of 1% Retinoids but they are a diluted form which usually contain much lower final concentrations. BioRenew uses Retinol 0.2% in an undiluted slow release form.


Niacinamide or Vitamin B3 is a very effective antioxidant. Although it is often overlooked by large department store brands, there are numerous clinical trials showing its efficacy to brighten a dull appearance and dramatically reverse common signs of aging such as fine wrinkling.

Most clinical trials have been studied between 4 - 5%. BioRenew uses Niacinamide 4% to enhance a youthful glow and diminish the appearance of an uneven skin tone.

If your skin is changing, is it time to rethink your skin care?